My psychiatrist is the only one of my Drs. I have seen in the last 2 weeks (Rheumatologist and Neurologist) taking my new nerve pain seriously and actively trying to help me control it instead of simply suggesting stop using that arm. (I’m a manual wheelchair user. That is not helpful advice!) I’ve been on the max dosing of the Lyrica/Cymbalta combo (for nerve pain) for so long he (and I) believe it is no longer working. (see my other post Wrist Saga part 2 for info on what is going on w/ pain).
From the research I have done into LDN - Basic PRO: it might work but researchers have no idea why. Basic CON: placebo effect and nothing more.
LDN sounds almost too good to be true. Whenever a drug states that it can treat multiple diseases with different causes (some LDN researcher’s claim it can help people with HIV/AIDS, those with auto immune disorders AND those with cancer) researchers start to get iffy and studies stop dropping out of the spotlight.
“Ironically, LDN promoters may in fact harm research into LDN by giving it a bad name. Researchers may be reluctant to hitch their careers, or funding agencies commit resources, to a treatment that has a dubious reputation. If the research is promising it will still get done, but if anything it is likely to be slowed by the efforts of the LDN promoters.”
The “N” part of LDN stands for Naltrexone.
“Naltrexone is approved by the …[FDA] for the treatment of addictions to opioids and alcohol. At the full recommended dose, Naltrexone blocks opioid docking sites on cells.
At significantly lower doses, Naltrexone has been prescribed as a treatment for a variety of diseases, including various types of cancers, HIV/AIDS, Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), emphysema, as well as multiple sclerosis (MS) and other autoimmune diseases.”
“Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn’s disease, multiple sclerosis, and complex regional pain syndrome. We review the evidence that LDN may operate as a novel anti-inflammatory agent in the central nervous system, via action on microglial cells. These effects may be unique to low dosages of naltrexone and appear to be entirely independent from naltrexone’s better-known activity on opioid receptors. As a daily oral therapy, LDN is inexpensive and well-tolerated. Despite initial promise of efficacy, the use of LDN for chronic disorders is still highly experimental. Published trials have low sample sizes, and few replications have been performed. We cover the typical usage of LDN in clinical trials, caveats to using the medication, and recommendations for future research and clinical work. LDN may represent one of the first glial cell modulators to be used for the management of chronic pain disorders.”
So far, LDN indicates the potential for translational research – nothing more.
“What about the clinical evidence? A search of PubMed for “low-dose naltrexone” reveals only pilot and preliminary studies. The quick bottom line is that there does not appear to be a single medical application of LDN (outside of addiction) that is supported by a class I clinical trial, let alone a consensus of rigorous studies. What we do see is a smattering of pilot studies for a few diseases.”
From what I can gather LDN has had no clinical trials and the research community is split in its opinion. I’m looking for someone who has used it and there response to it. (and other’s general thoughts on it - after doing some research of course).