My husband is on dose three of methotextrate for PA and its working for him. A little nausea but that's it for side effects so far. He takes folic acid the next day. Much better than a biologic We think.
Took it for RA seemed to help for awhile. It MUST be taken with Folic acid. I stopped taking it after I had to stop working. Could not afford to pay for lab work to make sure my liver function stayed reasonably normal. Main side effects for me was my skin in my mouth peeled all the time. Constant urinary and female infections. Not fun. Also very fatigued. When I stopped taking it my RA came back with a vengance. Sorry I do not have anything better to say.
@LMB Sorry to hear you had such a bad time with it. Have you managed to get your RA under control yet? I have ankylosing spondilitis (arthritis in the spine and other joints) and was managing well for 5 years with diet and supplements. Unfourtentaly, after my eye surgery I've had a really bad flare up and can't seem to get it under control, fed up and considering methotrexate for the first time.
MTX increased my bruising, A LOT, and is begining to make me a little anemic. Adding humira in a few days. I am kinda over the question of bad side effects. I just want to be able to participate in my 5 year ols life, my life w/ my husband and be able to work w/ out being in agony
I'm not on it but wonder if I should be. Due to the MTHFR genetic defect, where I don't absorb/metabolize B vitamins, it does me no good to take OTC vitamins. But they put me on L-Methylfolate, a more natural form of B vitamins and my pain level has decreased some. I recently found out I have pseudo dementia (unknown cause dementia), and it could be related to the B vitamin/gene defect, which affects the brain and pain.
I have AS and am taking methotrexate and Humira, along with Leflunomide. Humira was my most recent add, so I don't know how well it's working yet. The other two didn't seem to be helping all that much. Not really noticing any side effects at all, from anything.