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Pain or no Pain - is it All in the Genes?

Jul 01, 2014 9:25 AM

Article by Dr. Jan Dommerholt, PT, DPT, MPS, DAAPM


Why it is that some people get rear-ended and walk away without any long-term pain problems and others involved in seemingly the same kind of accident, become chronic pain sufferers? Persistent pain and other symptoms are common in a significant number of subjects. Typically, estimates range from 14% to 50% according to some studies, but one classic study suggested that 83% of interviewed subjects involved in a rear-end crash continued to experience symptoms more than 2 years following litigation.


Some lawyers, researchers, and even doctors do not believe that people involved in especially low speed crashes have any reason to develop persistent pain and suggest that these people may suffer from “litigation neurosis”. In other words, they believe that people fake injuries and pain to get more money in a lawsuit or because of psychological issues.


A recent study makes us rethink our assumptions. Researchers at the University of North Carolina School of Medicine have identified a biological reason why some people develop pain and others may not. They found that the injury itself may not be the most important factor, but the person’s stress response may dictate whether that individual is prone to develop chronic pain. The researchers focused on the so-called hypothalamic-pituitary adrenal (HPA) axis, a physiologic system that is directly involved in stress responses. They found that a variation in the gene encoding for one particular protein (referred to as FKBP5) was associated with a 20 percent higher risk of moderate to severe pain six weeks after a motor vehicle accident. In the study researchers looked at victims of sexual assault as well and they were also more likely to develop pain after six weeks of the assault when they had the same gene variation.


In summary, the study clarifies why some people develop persistent pain after experiencing trauma, while others do not. It is not yet clear what this means for therapeutic interventions. We do not know whether therapy, medications, or exercise for example can alter the dysfunctional stress response.


For more information, see
http://www.ncbi.nlm.nih.gov/pubmed/23707272
http://www.ncbi.nlm.nih.gov/pubmed/16157061


Dr. Jan Dommerholt
Fellow member of the CatchMyPain medical advisory board.

Jul 05, 2014 3:34 PM

I am finding other factors affecting my pain. I had a stroke last December (2013), and am noticing my reaction to my pain is changing. The stroke was in the pons area of the brain, the main 'switchboard' for communication from the brain to the body...at least this is what I has discovered through my own reading. The new issues of poor balance and low short term memory have pushed the pain level lower. I decided it is because the newer issues are requiring my full concentration 24/7.

My main concern now is being able to be able to function mentally so I can make a living. So far this is OK. I also have to watch my frame of mind since problems are affecting more of my daily functioning. For me, a good attitude is the key, even when experiencing pain. Memory issues mess this up at times as I am forgetting things constantly. What I am trying to do is form new habits to make uo for the memory loss. my progress is slow, but I am moving forward.

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