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Study of Low-Dose Naltrexone (LDN) for treatment of chronic pain.

Aug 20, 2017 12:26 PM

I came across this study earlier today that discusses the possibility of using Low-Dose Naltrexone (LDN) in the management of conditions such as Fibromyalgia, Crohn's Disease, MS, and Complex Regional Pain Syndrome. Naltrexone blocks opioid receptors and is used for substance abuse. It appears to have the opposite effect, in that it acts as an analgesic, when given at 1/10th of the dose for substance use. Unfortunately the 4.5 mg formulation that is used for Low-Dose Naltrexone is not currently available in the US or Canada.

I hope that research into this continues because it seems to be promising. What are your thoughts on this?


Aug 20, 2017 1:49 PM

I was in this for a while but it made my heart feel funny so I stopped. As far as helping with the pain I didn't notice much difference.

Aug 21, 2017 9:15 AM

Since it’s not available in the US, I can’t try it. I guess it’s a gamble like any other medicine. It’s either going to work or not work. LDN is similar to suboxone. Suboxone is prescribed in US. Not sure if that would work for pain. Ask your doctor next time you go in. If you find anything out, please let us know. Thank you

Aug 21, 2017 1:01 PM

I'm in the US and I got naltrexone.

Aug 21, 2017 2:04 PM

@Frustrated - thanks

Oct 18, 2017 2:00 PM

I just got a prescription for LDN. I guess you have to find the right doctor. I am getting mine from a compounding pharmacy in Colorado. They just mailed it out today. I can’t wait to try it.

Oct 18, 2017 5:01 PM

@LAT. Will you let us know how it's working for you?
And how did you approach your dr. about it , If you don't mind sharing.. TIA

Oct 18, 2017 8:48 PM

I will definitely update you once I start. I saw my primary doctor (very compassionate and just amazing) for a fibro follow up appointment since the rheumatologist wouldn’t follow. I asked her about LDN. She told me she wanted to help but was not an expert. Then she referred me to a functional medicine doctor (holistic and integrative). The FM doctor usually book six months out, but I got in within 4 weeks. This doctor spent 1.5 hours with me. She almost immediately diagnosed me with Lyme disease. I told her I don’t like medicine or pills but I was so desperate I would try something except not antibiotics. She just offered up LDN. This was an amazing set of events that just happened. I’m very grateful. I have a potential cause for fibro and now a potential treatment.

As far as asking your doctor, I would bring in some research. There are plenty of studies online that support the use of LDN and for fibromyalgia and other autoimmune disorders.

Oct 19, 2017 11:14 AM

I am so happy for you that you found an alternative doctor! I hope LDN works well for you and brings you much relief! I would love to know how you're doing with it... I need to take something to help with pain but I also can't take meds like opiates that I've been prescribed. Thank You so much for your reply, it gives me hope😊

Oct 19, 2017 2:36 PM

@Emerald I understand completely. I have a very difficult time with any medication, prescription or over-the-counter. I have severe reactions to a lot of them. I had my DNA tested and I am a fast metabolizer. That means to feel any relief, I would need 4 to 6 times the amount of pain reliever as the average person. I got really tired of taking medication as a Band-Aid. It only covers up the symptoms and does not fix the root cause of the problem.

The best part about LDN is it is supposed to fix the immune system which could definitely be the root cause of fibro and other diseases.

I will definitely keep you posted. Sending you some e tea positive energy. What state do you live in? Or what city? I could call my doctors office to see if I could find a functional medicine doctor in your area. Or you can call your insurance company or your doctors office and ask them.

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