Antibiotics. I always try large doses of high concentration cranberry pills first. For me I will take 5 or 6 pills of the 4200 mg each at bedtime (to change the pH of the urine in your bladder). The reason for the bedtime dose is also to keep the pH change in you bladder the longest time possible. Then I again take 3 pills at one time during the mid-day (same reason and mg). I do this for usually 4 days and it works for me. My urologist told me about this a couple of years ago. I try to keep antibiotics as last resort. The reasoning for the massive dose is the infection does not like and cannot grow if conditions are not hospitable. Also if having painful spasms while urinating AZO makes a great product over the counter that works great but you will pee bright/dark orange if you do not see the product ask the pharmacist it was called pyridium (check spelling) before it went OTC. Everyone will tell you to drink cranberry juice that is great BUT you cannot possibly drink enough of the juice to get the same amount of mg available in the pill. Not to mention the sugar that will make your infection growth worse. Stay hydrated you want to flush out the infection not concentrate it. This is what works for me and NOT a substitute for seeing your physician. If you are having multiple UTI'S see a urologist to figure out why. Best of luck to you.